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Leaky brain?? What is that?

Brain inflammation starts with the gut.

When you have intestinal permeability, AKA, "leaky gut," you get micro-tears in your intestinal lining. This means things like pathogens, bacteria, and food proteins get out and into the bloodstream provoking an immune and inflammatory response.

Inflammation can lead to the breakdown of the blood-brain barrier (BBB), resulting in what is

referred to as "leaky brain." When this happens neural messages are not as fast. Symptoms could look like brain fog, poor memory, anxiety, depression, fatigue, etc.

The immune cells in your brain are called microglia which are responsible for clearing toxins and protect the environment (the neurons) in the central nervous system. When there's a microbial invasion in the brain (like an infection, bacteria or pathogen), the microglia go into defense mode and release proinflammatory cytokines. They're purpose is to destroy the invader before damage occurs to the neural tissue.

The disruption to the BBB and increased inflammation can cause a shift and lead to permeability or leakiness and damage to the neurons.

The cellular damage that occurs as a result leads to the creation of neuronal protein fragments. Your immune system then develops antibodies against the damaged cellular protein, leading to neuro autoimmunity where your immune system attacks its own brain cells.

This neurodegeneration is a process that leads to conditions such as dementia, Alzheimer’s, and Parkinson’s, as well as , other memory and mood disorders.

If you'd like to be proactive supplementation can help reduce brain inflammation and prevent the activation of the microglia and the neurodegeneration that can occur.

Benefits of B Vitamins include the following:

~ Support the blood-brain barrier

~ Help convert food into energy

~ Combat neuroinflammation and supports cellular health

~ Creates new blood cells

~ Help to restore the integrity of the BBB

~ Support your metabolism

~ Reduce homocysteine levels (homocysteine is an inflammatory compound. If elevated, can contribute to the disruption of the BBB)

~ Maintain healthy skin

~ B12 Can help lower brain inflammation. A deficiency can lead to Alzheimer’s disease and supplementation can assist with prevention and treatment

  • B vitamins include B1, B2, B3, B5, B6, B7, B9 and B12. Together they are called B complex.


~ Is best known for it's anti-inflammatory and antioxidant properties

~ Reduces the permeability of the blood brain barrier (BBB)

~ Helps remove amyloid plaque on the brain which can help prevent Alzheimer's disease

~ Can inhibit the formation of reactive oxygen species (ROS) which helps in age-related brain diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease

~ Helps with the formation of new neurons (neurogenesis)

~ Has anti-tumor properties that helps reduce cell proliferation

2. NAC (N-acetyl-cysteine)

NAC is a Potent antioxidant. It supports glutathione levels in the body.

NAC also:

~ supports the regulation of immune cell messengers and modulation of immune responses

~ Helps neutralize oxidative compounds produced from inflammatory cell messengers, infection, and other toxins

~ Inhibits the cerebral inflammatory response

~ Protects against inflammation-induced dysfunction of the BBB

~ Prevents biofilm formation which bacteria produce to protect themselves and evade destruction

If you’d like to discuss supplements, reach out @JinjerRoot or via email at

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